CMAJ March 17, 2009; 180 (6). doi:10.1503/cmaj.080972.
© 2009 Canadian Medical Association or its licensors
All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.
Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
Sylvia H. Ley, RD MSc,
Stewart B. Harris, MD,
Mary Mamakeesick, RPN,
Tina Noon,
Edith Fiddler,
Joel Gittelsohn, PhD,
Thomas M.S. Wolever, MD PhD,
Philip W. Connelly, PhD,
Robert A. Hegele, MD,
Bernard Zinman, MD and
Anthony J.G. Hanley, PhD
From the Department of Nutritional Sciences (Ley, Wolever, Hanley), University of Toronto, Toronto, Ont.; the Center for Studies in Family Medicine (Harris), Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont.; the Sandy Lake Health and Diabetes Project (Mamakeesick, Noon, Fiddler), Sandy Lake, Ont.; the Center for Human Nutrition (Gittelsohn), Johns Hopkins Bloomberg School of Public Health, Baltimore, USA; the Department of Laboratory Medicine and Pathobiology (Connelly), University of Toronto, Toronto, Ont.; the Keenan Research Centre of the Li Ka Shing Knowledge Institute (Connelly); St. Michael's Hospital, Toronto, Ont.; the Robarts Research Institute and University of Western Ontario (Hegele), London, Ont.; the Division of Endocrinology (Zinman, Hanley), University of Toronto, Toronto, Ont.; the Leadership Sinai Centre for Diabetes (Zinman, Hanley), Mount Sinai Hospital, Toronto, Ont.; and the Samuel Lunenfeld Research Institute (Zinman), Mount Sinai Hospital, Toronto, Ont.

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Figure 2: Age- and sex-adjusted risk of type 2 diabetes associated with readily accessible clinical measurements.
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Figure 3: Age- and sex-adjusted risk of type 2 diabetes associated with impaired glucose tolerance and with metabolic syndrome. C statistics for metabolic syndrome, whether defined by the National Cholesterol Education Program criteria (0.668) or the International Diabetes Federation criteria (0.682), were not significantly different from the C statistic for impaired glucose tolerance (0.681) (p > 0.05 for comparisons of C statistics).
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